Insights: APOE, Klotho, and the Risk of Alzheimer’s Disease
It is extremely exciting that so much research is coming out on Alzheimer’s Disease and Dementia at the moment. The Lancet just published their 2024 report on Dementia prevention, intervention and care. The report identifies 14 modifiable risk factors, including new additions such as untreated vision loss and high LDL cholesterol, that could prevent or delay nearly half of dementia cases if addressed effectively. The Commission also underscores the importance
The Importance of Nutrition in Menopause and Peri-menopause
Menopause is hugely significant in a woman's life, bringing various physiological changes that can impact overall health. Nutrition plays a critical role in managing these changes, reducing symptoms, and preventing long-term health issues such as osteoporosis, cardiovascular disease, and metabolic disorders. Understanding Menopause and Peri-menopause Menopause marks the end of a woman’s menstrual cycles, typically occurring between 50-55. Peri-menopause, the transitional period leading up to menopause, can start years earlier and is
Insights into PCOS: Mitochondrial Dysfunction and Inflammation
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting many women of reproductive age. The WHO estimates that 8–13% of reproductive-aged women are affected. However, up to 70% of affected women remain undiagnosed worldwide – which is a shocking statistic. It can be poorly understood and clients are often left feeling helpless with very few options for treatment. One emerging area of research is the role of mitochondrial dysfunction
Peri-Menopause – we should be thinking about this earlier than we do
In July last year, I began feeling really unwell—extreme night sweats, shortness of breath, and profound fatigue. My first thought was, "Here it is, menopause." However, it turned out I had post-COVID pneumonia, which led to a week in the hospital and six months on prednisone. Fast forward to this July, and I was still struggling with the same symptoms. Much of it I attributed to Long COVID. But during
Mycotoxins and Neurologic Health
The impact of environmental toxins on health has been increasingly recognized, with mycotoxins emerging as significant contributors to neurological disorders. Mycotoxins, which are toxic secondary metabolites produced by fungi, can affect human health in various ways, including crossing the blood-brain barrier (BBB) and inducing neurotoxicity. Assessing mycotoxin exposure it crucial across many chronic disease conditions. For the sake of this post, I am only going to look at neurological health,
Understanding the Role of Homocysteine in Cognitive Decline
As we know, cognitive decline and neurodegenerative diseases, such as Alzheimer's, pose significant challenges to public health and are extremely traumatic for the affected families. There is so much to read but some emerging research highlights the role of homocysteine, an amino acid produced in the body, in these conditions. I heard this on a podcast the other day so decided to delve deeper. Elevated homocysteine levels have been linked to
Intermittent Fasting for Women
Intermittent fasting (IF) has a beneficial impact on insulin sensitivity, metabolic rate, and cellular repair processes. The role of autophagy, a cellular cleanup process that occurs during fasting, is a key benefit of IF. As a reminder, IF is important as it: reduces inflammation, lowering blood sugar levels, and improving heart health. contributes to better mental clarity and increased energy levels. aids in weight loss by reducing calorie intake and enhancing
Intermittent Fasting & Cognitive Function
I am often asked about Intermittent Fasting (IF) and weight loss. However, IF has gained significant attention in recent years for its potential benefits in promoting cognitive health and mitigating the effects of cognitive impairment. This makes it an even more interesting dietary intervention. For those of you who don’t know, the IF approach alternates periods of eating and fasting, inducing a metabolic switch from glucose to ketone bodies, which has
Polyphenols and the NF-κB Pathway: Gaining Traction for Neurological Disorders
Neurological disorders (NDs) represent a significant global health concern with an estimated 55 million people live with Alzheimer’s disease (AD). These disorders, which also include Parkinson’s disease (PD), depression, anxiety and various other conditions affecting the nervous system, result in a range of symptoms from cognitive deficits to motor dysfunction. The nuclear factor kappa B (NF-κB) pathway, known for regulating immune responses, cell division, and apoptosis (programmed cell death), plays
Fermented Foods: Should You Be Eating Them?
Fermented foods, like kefir, kimchi and sauerkraut, are really coming to the fore for their potential health benefits. But is there substance to these claims or is it just hype? In actual fact, recent research underscores the profound impact these foods can have on our overall health, particularly through their influence on gut microbiota, metabolic functions, immune health and chronic disease management. I’ve looked at multiple studies over the past