Neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS), and Huntington’s disease (HD) are often viewed through the prism of distinct symptoms and pathology. However, a recent review by Phillips and Picard challenges this perspective, introducing the concept of these conditions as "metabolic icebergs”. This framework emphasizes the underlying role of mitochondrial dysfunction as a unifying factor in their development and progression. The Metabolic Iceberg Model The

In their recent publication, Anderson et al. explore the ketogenic diet (KD) as a potential transdiagnostic intervention for neuropsychiatric disorders, presenting compelling evidence for its role in addressing shared pathophysiological mechanisms. The review delves into the science behind the diet's impact on mental health conditions, such as schizophrenia, bipolar disorder, and Alzheimer’s, while also discussing clinical outcomes and the importance of sustained ketone levels. Overview of the Article Neuropsychiatric disorders remain a